Papa Nicolsamide
ʻO Niclosamide kahi salicylanilide chlorinated waha, me ka hana anthelmintic a me ka hana antineoplastic.Ma ka hoʻoponopono waha, hoʻoulu ʻia ka niclosamide i ka hoʻohaʻahaʻa ʻana o ka ʻano ʻano ʻokoʻa o ka androgen receptor (AR) V7 (AR-V7) ma o ke ala proteasome-mediated.Hoʻohaʻahaʻa kēia i ka hōʻike ʻana o ka ʻano AR, keʻakeʻa i ka hana transcriptional AR-V7-mediated, a hōʻemi i ka hoʻopaʻa ʻana o AR-V7 i ka mea hoʻolaha gen prostate-specific antigen (PSA).Kāohi pū ʻo Niclosamide i ka AR-V7-mediated STAT3 phosphorylation a me ka hoʻāla ʻana.ʻAʻole kēia i ka hōʻailona AR/STAT3-mediated a pale i ka hōʻike ʻana i nā genes target STAT3.A pau, hiki i kēia ke keʻakeʻa i ka ulu ʻana o AR-V7-overexpressing cell cancer.ʻO ka ʻokoʻa AR-V7, i hoʻopili ʻia e ka splicing contiguous o AR exons 1/2/3/CE3, ua hoʻoponopono ʻia i nā ʻano ʻano cell cancer, a pili pū me ka piʻi ʻana o ka maʻi maʻi a me ke kūʻē ʻana i nā lāʻau lapaʻau AR-targeted.
Huina:
ʻO kēlā me kēia bolus cotnains 1250 mg niclosamide
Hōʻike:
No nā ruminants i hoʻopili ʻia i nā paramphistomes, cestodiasis, e like me ka moniezia pipi a me nā hipa, avitellina centripunctata, etc.
Ka nui a me ka hoʻohana ʻana:
Ma ka waha o kēlā me kēia 1kg kaumaha o ke kino.
Pipi: 40-60mg
Hipa: 60-70mg
Ka wā hoʻihoʻi:
Hipa: 28 lā.
Pipi: 28 lā.
Ka nui o ka pūʻolo: 5 papa no ka blister, 10 blister no ka pahu
